Study Guide_2nd_HE_BCH4054_Fa06

Study Guide_2nd_HE_BCH4054_Fa06 - Study Guide for BCH 4054,...

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Study Guide for BCH 4054, Hour Exam #2 Penny J. Gilmer Pentose phosphate pathway of alternative way to oxidize glucose in cytoplasm; know reactants products, and enzyme names Phase I with three reactions, two of which are oxidation steps, with each oxidation step generating NADPH; regulation in first oxidation step by NADPH (-) and acyl-CoA (-) Phase II with first step an oxidative decarboxylation followed by rearrangements of the five C sugars, going different directions depending on the needs of the cell, generating glycolytic intermediates, ATP, and NADPH, as needed Wernicke-Korsakoff syndrome; binding of TPP is weak Glucose-6-phosphate dehydrogenase deficiency Role of glutathione in preventing buildup of H 2 O 2 NO enhances glucose transport into cells Glucose Sensing Glucose transporters, GLUT 2 and GLUT4, are transmembrane glycoproteins in the plasma membrane; glucose equilibrates across the membrane Function of β –cells of pancreas is to sense glucose and respond with release of insulin; know series of steps in the response Once glucose is phosphorylated by hexokinase, charge gluc-6-P product stays inside the cell; product G-6-P inhibits the hexokinase Released insulin binds to liver cells and
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Study Guide_2nd_HE_BCH4054_Fa06 - Study Guide for BCH 4054,...

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