cancer table for notes.docx - Aspect of cancer Overview of...

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Aspect of cancer Main ideas Details Overview of cancer a. Definition b. Types c. Naming d. Stages Cancer is a term for disease in which abnormal cell division without control and invade the near by tissue What goes wrong in the cell cycle a. Checkpoints b. CDK/cyclins c. P53 G1 checkpoint: cell size, nutrients growth factor, DNA damage G2 checkpoint: DNA damage replication Spindle checkpoint: Chromosome attachment to spindle at metaphase plate b. Cyclins: regulatory protein, level cycle in the cell CDK P53: gene P53 plays a key role in G1/S restriction point. P53 protein halts cell division if it detects damaged DNA. Could be mutation that prevents these from working Tumor Growth/metastasis a. How are tumors formed b. How do cells metastasize c. Malignant vs benign Tumors are formed when cells in the body divide and grow at an excessive rate. Dead cells remain and form a growth known as a tumor Metastasize: The spread of cancer to the new part of the bod. Cancer cell must go through several steps to spread to new
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