Chapter 19 7th edition.ppt - Citric Acid Cycle-Aerobic...

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Citric Acid Cycle -Aerobic Catabolism -Also called Krebs cycle and TCA cycle -metabolites of nutrients are fed into the citric acid cycle as acetyl CoA or as some intermediate of the cycle -Intermediate products of the citric acid cycle can be removed to make macromolecules; Amphibolic Cycle -Glycolysis produces 2 ATP, but the citric acid cycle along with the electron transport chain produce 30-32 ATP
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Glycolysis : in the Cytosol Citric Acid Cycle : mitochondria; most steps take place in the matrix with the exception succinate dehydrogenase; FAD is linked to the inner mitochondrial membrane in the electron transport chain
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Pyruvate is transported into the mitochondria by a transporter Pyruvate Dehydrogenase Complex : pyruvate is converted to CO 2 and acetyl CoA Coenzyme, FAD, and NAD are needed 5 enzymes: -pyruvate dehydrogenase -dihydrolipoyl transacetylase -dihydrolipoyl dehydrogenase -pyruvate dehydrogenase kinase -pyruvate dehydrogenase phosphatase Coenzymes: lipoic acid, TPP (thiamine pyrophosphate) Converts pyruvate to acetyl CoA Control enzymes
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Step 1: Formation of Citrate -Oxaloacetate and acetyl CoA to Citrate and CoA-SH - Enzyme: Citrate Synthase -ΔG = -32.8kJ/mol; exergonic; hydrolysis of the thioester (CoA-SH) releases energy
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