T1 - NOTES 1.docx - PHARMOCKINETICS(PK WHAT HAPPENS TO DRUG...

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PHARMOCKINETICS (PK) - WHAT HAPPENS TO DRUG IN THE BODY - TIME ADMINISTERD/TIME ELIMINATED - Plasma drug levels over TIME - TYLENOL = 10-20 mcg/ml Therapeutic LEVEL - Pharmacokinetics is MOVEMENT through body PHARMACODYNAMICS - WHAT THE DRUG DOES TO THE BODY, EFFECTS - Ex) lowers body temp, replaces thyrxine, stops cell growth, reduces clots - PHARMACODYNAMICS IS WHAT THE MEDICINE DOES! DISTRIBUTION - Patients nutritional intake and hypoalbumenia can affect drugs getting to target tissue HALF LIFE Time it takes for plasma drug concentration to be reduced by 50% WHAT FACTORS INFLUENCE HALF LIFE? - Clearance - Volume of Distribution LARGE VOLUME OF DISTRIBUTION - This will have a wide distribution and LONGER HALF LIFE FIRST PASS EFFECT - Drugs Are rapidly metabolized by the liver and may have little if any desired action STORAGE RESERVOIRS Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage reservoir of the drug. Storage reservoirs: Increase the length of time a drug is available and active LOADING DOSE Rapidly achieves drug levels in the therapeutic range ONSET OF ACTION The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the: Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
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To determine if a drug is in the therapeutic range RECEPTORS - Large PROTEINS that determine relationship between dose/effect - Located on the outside to inside of cell, communicates what to do - Receptors INTERACT AND MEDIATE ACTION OF DRUGS - The goal of RECEPTORS = HIGH DEGREE OF SPECIFICITY QUIZ – RECEPTORS ARE: - Large proteins found on surface cell membranes and intercellularly that are continually regulated under influence of DNA - In the short term in a healthy patient, receptors numbers and sensititivty to specific drugs do not change - EPINEPHRINE – a FULL AGONIST – can simultaneously stimulate both alpha receptors in small arterioles and beta receptors in the lung - As more AGONIST drug are bound to specific receptors, a more vigoruous immediate pharmacological response is expected with each dose - EFFICACY - How much work a drug does - Expresses maximum effect of any dosage - EFFICACY looks at Y axis, magnitude of effect -
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