S. Male Reproductive system.docx

S. Male Reproductive system.docx - Male Reproductive system...

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Male Reproductive system Weeks 1-6: embryo remains in sexually indifferent or undifferentiated stage. Phenotypically. -Week 4: wall of yolk sac protrudes germ cells XY for mall and migrate toward gonads. Week 7: begins phenotypic sexual differentiation Week 12: Female or male characteristics or external genitalia recognized. Fetus has risk for intersexuality if any deficiency 1) Short arm of Y has gene important for testicle development 2) After formation of testicle, hormones form testicle control genitalia organ growth. a. Leydig cells secrete testosterone : under control of LH b. Placenta secretes testosterone 3) Embryonic intermediate mesoderm gives rise to mesonephric and paramesonephric ducts a. Testicle sertoli cells secrete anti-mullarian hormone to prevent development of paramesonephric duct in male. 4) Deficiency of testosterone from placenta and testicle causes failure of descent of testicle from ab to scrotum (ectopic) 5) Deficiency of DHT leads to non-developed testicle and genitalia 6) Deficiency of these hormones lead to affected sperm production (aspermia) 7) Deficiency of these hormone can cause “Sertoli only cell” syndrome. a. No seminiferous tubule, just sertoli cells. b. No sperm production c. Sertoli in adult male secrete inhibin that controls production of sperm 8) Need small amounts of estrogen for sperm productions a. Conversion of testosterone to estrogen by aromatase enzyme 9) Male genetic disorder: Klienfelter syndrome; XXY 10) May have sexual activity, but no reproductive life.
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