BME 201 HW #1.docx

# BME 201 HW #1.docx - Professor Kaiming Ye BME 201...

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Professor Kaiming Ye BME 201 Homework #1 1. Human cells in various parts of the body have different organelles based on their function. Some examples include Red Blood Cells which contain no nucleus, and muscle cells which have an excess of microfilaments. 2. Calculation of the volume occupied by 10 billion proteins: 10 billion proteins x 450 amino acids per protein x 110 daltons = 495,000,000,000,000 daltons = 8.21x10^-10 grams / 1.4 g/cm^3 = 5.86x10^-10 cm^3 = 5.86 x 10^-6 μm^3. Calculation of the fraction of a cells volume this occupies: 5.86x10^-6 μm^3 / 5000 μm^3 = 1.17x10^-9 μm 5.86x10^-6 μm^3 / 1000 μm^3 = 5.86x10^-9 μm 10 billion proteins therefore would occupy just one billionth of a liver cell’s volume and about 6 billionths of a pancreatic exocrine cell’s volume. 3. If a protein has no sorting cell, then it won’t be brought to any particular organelle. Most likely, it will either remain in the endoplasmic reticulum where it was made or possibly get into the cytosol until it begins to denature, at which point a lysosome will come and break it down.
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