T3 CHART - UTI PART 2 FINAL.docx - UTI | DEFENSE AND OTHER...

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Urinary Tract Infections | UTI Host Defenses The defense system is challenged by the virulence of the pathogen #1 DEFENSE = WASHOUT PHENOMENON - #1 INCREASE FLUIDS, PEE POST SEX! Protective MUCIN layer that lines the bladder and protects against bacteria Local immune system reactions - IgA and phagocytic cells remove the bacteria - THESE ARE GOOD! Host- Agent interactions MUCIN LAYER Epithelial cells that line the bladder produce protective substances Believed that by binding water provides a barrier between the bacteria and the bladder epithelium POST MENOPAUSAL WOMEN HAVE DECREASED MUCIN LAYER (and decreased Estrogen) Role of estrogen as older women and post menopausal women do not have as much mucin Other risk DIABETES MELLITUS PATIENTS MORE AT RISK FOR COMPLICATIONS SUCH AS PYELONEPHRITIS Hospital Acquired Catheterization Instrumentation Diabetics Women who are diabetic are more at risk More at risk for fungal infections and for gram negative pathogens other than E.coli Other Factors
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