Week 5 Discussion Post.docx

Week 5 Discussion Post.docx - NURS 6521N-36 Advanced...

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NURS 6521N-36 Advanced Pharmacology Week 5 Discussion Post – Pharmacotherapy of neurological disorders Cynthia Nwokocha June 26, 2017 Pharmacotherapy of Neurological Disorders Neurological disorders are diseases of the brain, spine and the nerves that connect them. There are more than 600 diseases of the nervous system, such as dementia, brain tumors, epilepsy, Parkinson's disease and stroke (National Institute of Neurological Disorders and Stroke, 2013). For this week’s discussion post, I will go over the pharmacotherapy of dementia. Dementia is a general term that describes a wide range of symptoms associated with the decline in memory or critical thinking or judgment skills severe enough to reduce a person's ability to perform activities of daily living. Alzheimer's disease accounts for 60 to 80 percent of cases (Alzheimer Association, 2017). Vascular dementia, which occurs after a stroke, is the second most common dementia type. But there are many other conditions that can cause symptoms of dementia, including some that are reversible, such as thyroid problems and vitamin deficiencies. Treatment Drugs to specifically treat dementia and other conditions associated with it do not halt the disease or reverse existing brain damage, they only improve symptoms and slow the progression of the disease; thus, improving an individual’s quality of life. One class of drugs, called cholinesterase inhibitors, includes donepezil, rivastigmine, and galantamine. These drugs can temporarily improve or stabilize memory and thinking skills in some people by increasing the activity of the cholinergic brain network (National Institute on Aging, 2013). The drug memantine is in another class of medications called NMDA receptor agonists, which prevents declines in learning and memory. NMDA receptor agonists work by regulating the activity of the neurotransmitter glutamate. When glutamate activity levels
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