Quiz2Questions.docx - Question 1 The elderly are at high risk of ADRs due to Having greater muscle mass than younger adults leading to higher volume of

Question 1. The elderly are at high risk of ADRs due to: Having greater muscle mass than younger adults, leading to higher volume of distribution The extensive studies that have been conducted on drug safety in this age group The blood-brain barrier being less permeable, requiring higher doses to achieve therapeutic effect CORRECT Age-related decrease in renal function Question 2. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the: Minimum adverse effect level Peak of action CORRECT Onset of action Therapeutic range Question 3. Genetic polymorphisms account for differences in metabolism, including: Poor metabolizers (PMs) that lack a working enzyme Intermediate metabolizers (IMs) that have one working, wild-type allele and one mutant allele Extensive metabolizers (EMs), with two normally functioning alleles CORRECT All of the above Question 4. Steady state is: The point on the drug concentration curve when absorption exceeds excretion

CORRECT When the amount of drug in the body remains constant When the amount of drug in the body stays below the minimum toxic concentration (MTC) All of the above Question 5. When obtaining a drug history from Harold, he gives you a complete list of his prescription medications. He denies taking any other drugs, but you find that he occasionally takes aspirin for his arthritis flare-ups. This is an example of: