bioassay - C. Plotting the data D. Probit transformation E....

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PESTICIDES, THE ENVIRONMENT AND HUMAN HEALTH Entomology 3070 and Toxicology 3700 Fall 2008 How Toxicity is Determined & PPM calculations Reference: Dosage and other factors influencing toxicity, by W.J. Hayes Jr., In "Handbook of Pesticide Toxicology" Ed. by Hayes and Laws. Vol 1, Chapter 2. Sipping from a Poisoned Chalice, Science, 302:376-379 (2003) Objectives: Understand how bioassay data are used to determine toxicity Comprehend why the data is treated this way Understand the limitations of the analysis Be able to solve problems relating to PPM calculations 1. Bioassay A. Definition B. End points 2. Evaluation of a bioassay A. % kill vs. dose B. Weber-Fechner Law
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Unformatted text preview: C. Plotting the data D. Probit transformation E. Probit analysis F. Properties of the log-dose probit (LDP) line G. Limitations in the analysis of bioassay data 3. Calculations PPM 1 part in 1,000,000 parts THIS IS THE STANDARD UNIT USED FOR ALL MEASUEMENTS OF TOXINS IN THE ENVIRONMENT!!! How much is 1 PPM? Conversion factors to memorize for 1 PPM solid in a solid 1 ug/g solid in a liquid 1 mg/l liquid in a liquid 1 ul/l Also: PPB, PPT Homework Problem: An apple weighing 150 grams contains 1 PPM Alar. If you eat the whole apple how much Alar would you have consumed? Would you be in danger of having severe acute toxicity effects from this dose?...
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