Unit 1 Exam.docx - Unit 1 Practice Exam Review PI 4 5...

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Unit 1 Practice Exam Review PI 4, 5, bisphosphate can be cleaved by phospholipase C to initially generate which of the following second messengers? Diacylglycerol (DAG) and Inositol 1, 4, 5 phosphate (IP3) In pyrimidine synthesis, uracil can feedback and inhibit which of the following enzymes? Carbamoyl phosphate synthase II Transaminatino is the first step in amino acid metabolism and it involves which of the following processes? The transfer of an amine group from an amino acid to a keto acid Water is a key component of biological systems. Which of the following statements is false with regards to the chemical properties of water? Water has a very large dissociation constant A 40-year-old male comes in to the doctors office with severe pain in his big toe. He is diagnosed with gout. Allopurinol is administered and this drug will inhibit which of the following enzymes? Xanthine Oxidase Folate is an essential compound in the synthesis of nucleotides. All of the following nucleotides require folate for synthesis except: dCTP Buffers are essential components to biological systems. They consistent of a weak acid (HA) and conjugate base (A-). Which of the following represents the correct pairing of a weak acid and conjugate base? CH3COOH (HA); CH3COO- (A-) In the case of an individual who is autosomal recessive for a deficiency in cystathione – beta – synthase. Which amino acid becomes essential? Tyrosine Cortisol is a steroid hormone and it signals via which of the following mechanisms? Nuclear receptors Which of the following is an example of enzyme regulation through covalent modification? Phosphorylation of muscle glycogen phosphorylase Starting at the level of the receptor, order the list of activites (given below) to illustrate the sequence of events that occurs following ligand binding of a tyrosine kinase receptor. 1. Activation of Ras-GTP 2. Recruitment of SOS (GEF) 3. Autophosphorylation of the intracellular domain of the receptor 4. Association of Grb2 to the receptor through SH2 domains 5. Association of Ras-GTP with Raf 3, 4, 2, 1, 5 In a repressible operon, when the co-repressor is absent which of the following statements is true?
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The repressor is active Order the following statements to illustrate the correct cascade of events that occurs after ligand binding of G-protein coupled receptor (heptahelical receptor) 1. Degradation of cAMP by phosphodiesterase 2. Dissociation of Gbeta and Ggamma subunits 3. G protein exchanges GTP for GDP in the G-alpha subunit 4. Activation of adenylyl cyclase to generate cAMP 3, 2, 4, 1 The transport of glucose from the intestinal lumen to the enterocytes is dependent on which of the following processes? The maintenance of a sodium gradient across the intestinal lumen and the enterocyte All of the following can be found within the transcribed region of a eukaryotic gene except TATA box Which figure depicts translational initiation?
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