Absolute Configuration - Stereochemistry: An Inquiry-based...

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Stereochemistry: An Inquiry-based Approach Banaz al Khalidi, Benjamin Si, Leanne Tran CHM299Y Research Project Under the direction of: Professor Cecilia Kutas Department of Chemistry University of Toronto
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PART 1: ABSOLUTE CONFIGURATION Leanne Tran You will need an internet connection to view the videos in the presentation. Please turn on your computer speakers to hear the audio that accompanies one of the videos. Credit: All three-dimensional models made using ArgusLab 4.0.1 Copyright 1997-2004 Mark Thompson and Planaria Software LLC
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Welcome to Absolute Configuration! If you ever need my help, just click on the Hint link after a question. I like to think of absolute configuration like a tricycle: Hi, I’m Molly Cule! The first three tricycles are not facing the right way, and the shape is all wrong. Only the last tricycle shown bottom right will work! In chemistry, many molecules have to have a specific orientation in 3D space, like the tricycle, in order to work properly. For example, one form of ibuprofen is an effective pain reliever while the other form slows the action of the first form. Source: http://imagecache2.allposters.com/images/pic/AIM/A3893_CAT~ Little-Tricycle-Posters.jpg
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What you need to know Cahn-Ingold-Prelog Sequence Rules How to zoom in on stereocenters within large molecules Source: http://oncampus.richmond.edu/academics/education/projects/w ebunits/adaptations/images/waldo2.gifhttp://z.about.com/d/puz
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This note was uploaded on 10/29/2008 for the course CHM 151 taught by Professor Dong during the Spring '08 term at University of Toronto- Toronto.

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Absolute Configuration - Stereochemistry: An Inquiry-based...

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