Fatty Acid Synthesis copy

Fatty Acid Synthesis copy - Kho Kashfi, PhD, MSc, LRSC...

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Fatty Acid Synthesis Kho Kashfi, PhD, MSc, LRSC QuickTimev and a TIFF (Uncompressed) decompressor are needed to see this picture. QuickTimev and a Photo - JPEG decompressor are needed to see this picture. Quick GIF de are nee
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Acetyl CoA The Center of Lipid Metabolism
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Overview of Acetyl CoA Metabolism QuickTime x and a TIFF (Uncompressed) decompressor are needed to see this picture.
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Precursors of Acetyl CoA Acetyl CoA is at the center of lipid metabolism. It is produced from: • Fatty acids • Glucose (through pyruvate) • Amino acids • Ketone bodies
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Products of Acetyl CoA Metabolism It can be converted to fatty acids, which in turn give rise to: • triglycerides (triacylglycerols) • phospholipids • eicosanoids (e.g., prostaglandins) • ketone bodies It is the precursor of cholesterol, which can be converted to: • steroid hormones • bile acids It produces, generated by the complete oxidation of acetyl CoA to carbon dioxide and water through the tricarboxylic acid cycle and oxidative phosphorylation.
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QuickTimeû and a TIFF (Uncompressed) decompressor are needed to see this picture. Two parts. 1. Acetyl group 2. Coenzyme A • Beta-mercaptoethylamine • Pantothenic acid (not synthesized in man, an essential nutrient) • Phosphate • 3', 5'-adenosine diphosphate Structure of Acetyl CoA
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Function of CoA CoA is a commonly used carrier for activated acyl groups (acetyl, fatty acyl and others). The thioester bond which links the acyl group to CoA has a large negative standard free energy of hydrolysis (-7.5 kcal/mole). This qualifies it as a high energy bond, and explains why an acyl group attached to CoA in this manner is considered to be activated.
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De novo Synthesis of Fatty Acids
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Overview Fatty acid synthesis is the process of combining eight two-carbon fragments (acetyl groups from acetyl CoA) to form a 16-carbon saturated fatty acid, palmitate. Palmitate can then be modified to give rise to the other fatty acids. These modifications may include: • chain elongation to give longer fatty acids, such as the 18-carbon stearate. • desaturation, giving unsaturated fatty acids.
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Tissue locations Fatty acid synthesis occurs primarily in the cytoplasm of these tissues: • liver • adipose (fat) • central nervous system • lactating mammary gland
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Reactions Sum of the reactions:
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Glucose -----> 2 pyruvate ------------> 2 acetyl-CoA This process is somewhat roundabout. 1.
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This note was uploaded on 11/04/2008 for the course BIOCHEM 1 taught by Professor Kashfi during the Spring '08 term at SUNY Old Westbury.

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Fatty Acid Synthesis copy - Kho Kashfi, PhD, MSc, LRSC...

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