Beta Oxidation - Fatty Acid Oxidation Kho Kashfi PhD Oils...

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Unformatted text preview: Fatty Acid Oxidation Kho Kashfi, PhD Oils and fats Meats & proteins Dairy Breads and Cereals Fruit & vegetables Salt Salt Sugar Sugar Storage and Mobilization of Fatty Acids • TGs are stored in adipocytes, and fatty acids are released to supply energy demands • A hormone-sensitive lipase converts TGs to free fatty acids and glycerol • At low carbohydrate and insulin concentrations, TG hydrolysis is stimulated by increased epinephrine (binds to β-adrenergic receptors, and activates cAMP-dependent protein kinases) Triacylglycerol degradation Fatty Acid Oxidation • The β-oxidation pathway degrades fatty acids two carbons at a time • Three stages: (1) Activation of fatty acids in the cytosol (2) Transport into the mitochondria (3) Degradation to two-carbon fragments (as acetyl CoA) in the mitochondrial matrix Carnitine Palmitoyltransferases Acyl-CoA Synthetase: Fatty acid + ATP + CoASH Acyl-CoA + AMP + PP i Carnitine Palmitoyltransferase: Acyl-CoA + Carnitine Acyl-Carnitine + CoASH Carnitine-Acylcarnitine antiport protein: Acyl-Carnitine Carnitine Mitochondrial Fatty Acid Oxidation Fatty Acid Synthesis Fatty Acid Synthesis Pathway Pathway Acetyl-CoA Carboxylase: Acetyl-CoA + ATP + HCO 3 – Malonyl-CoA + ADP + P i Fatty Acid Synthetase: Acetyl-CoA + 7 Malonyl-CoA + 7 NADPH Palmitate + 7 CoASH + 7 CO 2 + 7 NADP + + 7 H + Inhibits Fatty Acid Oxidation Carnitine Palmitoyltransferases Control Points for Intracellular Fatty Acid Transport Control Points for Intracellular Fatty Acid Transport ( C P T’s ) ( C P T’s ) CPT-I CPT-I CPT-II CPT-II Acyl-CoA Synthetase Antiport Protein Outer membrane Inner membrane Malonyl-CoA CPT-II Fatty acid + CoA+ ATP Acyl-CoA Acylcarnitine Acylcarnitine Acyl-CoA Carnitine ACC-II Acetyl-CoA CPT-I...
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This note was uploaded on 11/04/2008 for the course BIOCHEM 1 taught by Professor Kashfi during the Spring '08 term at SUNY Old Westbury.

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Beta Oxidation - Fatty Acid Oxidation Kho Kashfi PhD Oils...

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