Week 9-3

Week 9-3 - The flow of genetic information Outline the...

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The flow of genetic information Reading assignments: Molecular Biology of the Gene (Watson, 6th ed) chapter 2, page 28-41 chapter 15, page 525-538. Outline the central dogma the genetic code mutations
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DNA is the genetic material
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Genes (DNA) control amino acid sequence in proteins (Vernon Ingram, 1957)
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DNA is not the direct template of protein synthesis DNA protein ?
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RNA is a different kind of nucleic acid DNA: deoxyribonucleic acid RNA: ribonucleic acid
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RNA contains Uracil G A T C G A U C
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RNA is synthesized upon DNA template by RNA polymerases template strand coding strand
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Three types of RNA molecules messenger RNA (mRNA): gene-specific, contains future protein sequence information. transfer RNA (tRNA): transfer specific amino acid to the site of protein synthesis. ribosomal RNA (rRNA): structural component of ribosomes.
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mRNA is the template of protein synthesis tRNAs bring the amino acids.
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The Central Dogma
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RNA can be used as template to synthesis DNA DNA RNA protein replication transcription translation reverse transcription
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Determining the genetic code 4 nucleotide ~ 20 amino acid 1 nucleotide/amino acid = 4 amino acids 2 nucleotides/amino acid = 16 amino acids 3 nucleotides/amino acid = 64 amino acids synthetic RNA template peptide UUUUUUUUUUUU PhePhePhePhe
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the genetic code codon degeneracy start codon stop codon
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tRNA contains anticodon attaches amino acid
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Week 9-3 - The flow of genetic information Outline the...

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