practice midterm 2 key

practice midterm 2 key -...

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(Multiple choice problems are worth 3 points each). 1) Cyclin-dependent kinase (CDK) regulates replication initiation in eukaryotes by: a) preventing assembly of pre-replicative complexes during S, G2, and M phase b) activating pre-replicative complexes when cells enter S phase c) phosphorylating replication proteins d) all of the above e) none of the above 2) The proofreading function of DNA polymerases is: a) 5’ to 3’ exonuclease b) 3’ to 5’ exonuclease c) 5’ to 3’ endonuclease d) 3’ to 5’ endonuclease 3) How many telomeres are found in a human sperm or egg? a) 23 b) 46 c) 92 d) 84 4) Holliday junction migration is promoted by: a) RecA b) SSB (single-strand binding protein) c) RuvB helicase d) PCNA 5) With respect to DNA topology, DNA replication causes: a) positive supercoiling ahead of the replication fork b) DNA unwinding at/behind the replication fork c) catenation of DNA ahead of the replicaton fork d) all of the above 6) Making a specific gene deletion in any organism requires: a) transposon mutagenesis b) knowledge of the gene’s function c) a haploid cell d) homologous recombination 7) A diploid yeast cell has a normal and a mutant allele of a gene involved in biosynthesis of histidine. A haploid yeast cell with the mutant allele of this gene is unable to grow without histidine added to its growth medium; however, the diploid cell described above is able to grow without added histidine. This is due to: a) complementation b) DNA repair c) Homologous recombination d) All of the above 8) (4 pts.) Draw a replication fork in the process of DNA replication.
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This note was uploaded on 11/02/2008 for the course BISC 320L taught by Professor Baker,aparicio during the Fall '07 term at USC.

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practice midterm 2 key -...

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