lectures 10-3-10-6

lectures 10-3-10-6 - TheRepliconModel...

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The Replicon Model Replication is controlled by a DNA sequence called a replicator that binds an “Initiator” protein. The initiator protein regulates replication of the DNA DNA synthesis actually begins at the origin, which is usually within or adjacent to the replicator.
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The Roles of the Initiator Initiator binds DNA. Initiator unwinds (a little) DNA at the origin. Initiator recruits other replication proteins.
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Genetic identification of replicators
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The Eukaryotic Cell Cycle The major events of cell division, DNA replication and chromosome segregation, are separated in time, into cell cycle phases. During the Gap phases (G1 and G2) checkpoints ensure that all is well with the DNA and segregation machinery, before allowing DNA replication (S phase) and mitosis (M) to commence. The major regulatory decision to enter a new cell cycle occurs in G1. Once S phase has begun, the cell is committed to completing the cycle.
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lectures 10-3-10-6 - TheRepliconModel...

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