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9-22 24 - Chromatin structure Outline nucleosome structure...

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Chromatin structure Reading assignments: Molecular Biology of the Gene (Watson, 6th ed) chapter 7 p157-192 Outline nucleosome structure and assembly chromatin structure and regulation
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Bacterial DNA is negatively supercoiled
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Eukaryotic chromatin is compacted by histones Histones are major chromosomal proteins in enkaryotes. There are five major histones: H1, H2A, H2B, H3 and H4. They are small, highly basic, very abundant proteins, and are among the most conserved proteins in evolution.
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Histones are small, basic proteins Most of histone-DNA interactions are mediated by H- bonds between the protein and the oxygen atoms in the phosphodiester backbone.
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of eukaryotic chromosomes 147 bp of DNA wrapped around a histone core. Between each nucleosome is a region of DNA called the linker , which varies in size, typically 20-60 bp. Compact DNA sixfold.
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9-22 24 - Chromatin structure Outline nucleosome structure...

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