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Unformatted text preview: Neurotransmitter Receptors
Dr. McKemy 9/15/2008 A neurotransmitter can affect the activity of a postsynaptic cell via ionotropic and metabotropic receptors Ligand-gat ed ion channels ionot r opic r ecept or s "fast " r ecept or (1 msec) Signal is i ntr amolecular ly coupled.
Opens ion channels t o pr oduce EPSPs and I PSPs Ligandgated ion channels Composed of 7-t r ansmembr ane helices. Called ser pent ine r ecept or s Met abot r opic r ecept or "slow" r ecept or (100 msec) Signal is i nter -molecular ly coupled. Act ivat es int r acellular messenger s t hat open (or close) ion channels Act ivat es int r acellular messenger s t hat act on ionot r opic r ecept or s. H omeost asis and development (gene t r anscr ipt ion) Gprotein coupled receptors Activation of ACh receptors at neuromuscular synapses Opening of Ach receptors The influence of the postsynaptic membrane potential on end plate currents Na+ and K+ movements during EPCs and EPPs Summation of postsynaptic potentials The structure of the nACh receptor/channel ...
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This note was uploaded on 11/02/2008 for the course BISC 421 taught by Professor Hirsch,liman,quick during the Fall '08 term at USC.
- Fall '08