Synaptic Transmission 9-12-08

Synaptic Transmission 9-12-08 - Synaptic Transmission Dr....

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Synaptic Transmission Synaptic Transmission Dr. McKemy 9/12/2008
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Synaptic Transmission Synaptic Transmission This is cell-to-cell communication that proceeds in one direction. Occurs at synapses : site where two cells come in contact. When an AP arrives at the axon terminal of a presynaptic cell . Local increase in cytoplasmic Ca 2+ triggers fusion of synaptic vesicles . Neurotransmitter is released into the synaptic cleft . Binds to specific receptors on the postsynaptic cell .
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Electrical and chemical synapses differ in their  Electrical and chemical synapses differ in their  transmission mechanisms transmission mechanisms
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Structure and function of gap junctions at electrical  Structure and function of gap junctions at electrical  synapses synapses
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Sequence of events involved in transmission at a  Sequence of events involved in transmission at a  typical chemical synapse typical chemical synapse 1. Transmitter is stored in synaptic vesicles. 1. An AP enters the presynaptic nerve terminals. 1. Depolarization opens voltage- sensitive Ca 2+ channels. 1. The influx floods the terminal with Ca 2+ . 1. The Ca 2+ causes the synaptic vesicles to fuse with the membrane. 1. Release the transmitters.
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1. Transmitter diffuses across the cleft to the postsynaptic cell membrane. 1. Transmitters binds to their cognate receptors. 1. Postsynaptic ligand (transmitter) gated ion channels open or close. 1. The postsynaptic current can be either excitatory or inhibitory. 1. This current changes the excitability of the cell. 2. Excitatory leads to depolarization and AP generation. 1. Increase in tonic activity 3. Inhibitory leads to hyperpolarization. 1. Decreased tonic activity. 1. The vesicular membrane is retrieved from the plasma membrane and recycled. Sequence of events involved in transmission at a  Sequence of events involved in transmission at a  typical chemical synapse typical chemical synapse
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Loewi’s experiment demonstrating chemical  Loewi’s experiment demonstrating chemical  neurotransmission neurotransmission While living in Graz, Austria in 1921, Loewi dreamed of an experiment
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Synaptic Transmission 9-12-08 - Synaptic Transmission Dr....

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