Intracellular Signal Transduction 9-19-08

Intracellular Signal Transduction 9-19-08 - Intracellular...

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Unformatted text preview: Intracellular Signal Intracellular Signal Transduction Transduction Dr. McKemy 9/19/08 Chemical signaling mechanisms Chemical signaling mechanisms Synaptic signaling Paracrine: Secreted molecules act locally. Do not diffuse far. Endocrine: Hormone signaling. Act on targets cells some distance away. Usually carried by the blood or other extracellular fluids. Amplification in signal transduction pathways Amplification in signal transduction pathways An important property of the activation of cell-surface receptors is the amplification of the input signal. A single ligand-bound receptor can activate >100 G-proteins. Several hundred cAMP molecules. Down stream, the process can be further amplified. Three classes of cell signaling molecules Three classes of cell signaling molecules Categories of cellular receptors Categories of cellular receptors G-protein coupled receptors G-protein coupled receptors Largest family of cell surface receptors. 5% of the genes in the nematode C. elegans . Over 1000 involved in the sense of smell alone. Signaling molecules range from proteins to small peptides, amino acid derivatives, and fatty acids. Despite their diversity, all have the same general structure....
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This note was uploaded on 11/02/2008 for the course BISC 421 taught by Professor Hirsch,liman,quick during the Fall '08 term at USC.

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Intracellular Signal Transduction 9-19-08 - Intracellular...

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