Synaptic Plasticity 9-22-08

Synaptic Plasticity 9-22-08 - Synaptic Plasticity I:...

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Synaptic Plasticity I: Synaptic Plasticity I: Learning and Memory Learning and Memory Dr. McKemy 9/22/08
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Forms of Synaptic Plasticity Forms of Synaptic Plasticity Connections between neurons are a dynamic process. Changes in synaptic transmission is referred to as “Synaptic Plasticity”. Types: Synaptic Facilitation Two or more action potentials that occur within a few milliseconds Rapid increase in synaptic strength that can last for tens of milliseconds. Synaptic Depression During sustained synaptic activity the amount of neurotransmitter released declines Synaptic Potentiation Similar to Facilitation, but occurs over tens of seconds to minutes Synaptic Augmentation Over a few seconds
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Synaptic facilitation Synaptic facilitation Occurs when two or more APs reach the nerve terminal within a few millisec. Results in prolonged Ca 2+ levels. Rates of Ca 2+ removal are slow. Ca 2+ “builds up” in the nerve terminal . Subsequent APs release more neurotransmitter.
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Synaptic facilitation Synaptic facilitation Interval between AP is important.
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Synaptic Plasticity 9-22-08 - Synaptic Plasticity I:...

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