Lecture 5-cont'dMetabolism

Lecture 5-cont'dMetabolism - How to lower E a ACTIVE SITE...

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Metabolism: How the cell uses chemistry to get things done Catabolic Pathways Anabolic Pathways
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All metabolic pathways are subject to the 2 laws of thermodynamics 1 st law: Energy 2 nd law: Entropy
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2 types of Chemical Reactions Spontaneous Non-spontaneous Chemical Reactions in the cell use enzymes
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Gibbs Free Energy Spontaneous Non-spontaneous Chemical Reactions in the cell use enzymes
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How to describe Free Energy change over the course of a reaction
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Reactions in Real Life: Activation Energy
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Enzymes Speed up Reactions by lowering Activation Energy (E a )
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Spontaneous by VERY slow—takes decades In the body, an enzyme (sucrase) speeds up the reaction (secs)
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Unformatted text preview: How to lower E a ? ACTIVE SITE: the part of the enzyme that binds the substrate a pocket for the substrate formed by amino acid side chains of the enzyme SPECIFICITY: the active site of the enzyme creates a fit between enzyme and substrate That is specific for that reaction only (lock and key) INDUCED FIT: Substrate binds at active site Conformational change occurs in enzyme--holds onto the substrate more tightly like a clasping handshake Substrate Substrate bound to Enzyme Notice interactions between substrate and amino acids in the active site of the enzyme Induced Fit of Enzyme to Substrate...
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Lecture 5-cont'dMetabolism - How to lower E a ACTIVE SITE...

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