test1_answers - Principles of Drug Action (BIO 365) Test #1...

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Principles of Drug Action (BIO 365) Test #1 Name:_____________________________ February 19, 2007 Each of the 16 multiple choice questions is worth 0.75 marks out of 30 . 1. The antipsychotic haloperidol is sold under the tradenames Haldol and Bioperidol, among others. What kind of name is Haldol? A. Proprietary. B. Non-proprietary. C. Chemical. D. Generic. E. Common. 2. Complete the following sentence. Deviation from linearity of drug absorption rate versus Pm/b in the small intestine is due to A. an unstirred water layer acting as a hydrophobic barrier. B. an unstirred water layer acting as a hydrophilic barrier. C. large drug molecular size. D. small drug molecular size. E. the alkaline environment found in the small intestine. 3. Which one of the following statements is FALSE ? A. A fast onset of action is seen following inhalation of gases or vapours. B. Aqueous solutions are rapidly absorbed after i.m. injections, while drugs suspended in oil take longer. C. A suppository is a form of topical drug administration. D. Drugs administered sublingually are not subject to the first pass effect. E. Only small volumes of drugs can be administered subcutaneously. 4. Pinocytosis is A. mediated by aquaporins. B. mediated by connexins. C. a process that only occurs down drug concentration-gradients. D. a form of facilitated drug diffusion. E. the ingestion of fluid by cells, via cell membrane invagination. 5. Which of the following make up the blood:brain barrier A. Capillaries with maculae B. Occluded capillaries C. Fenestrated capilaries D. All of the above E. None of the above 6. Which one of the following statements about blood flow into and from the liver is TRUE ? Blood flows from the A. hepatic vein to liver sinusoids to central vein to portal vein. B. portal vein to liver sinusoids to central vein to hepatic vein C. portal vein to liver sinusoids to central vein to hepatic artery. D. hepatic artery to liver sinusoids to central vein to portal vein E. portal vein to central vein to liver sinusoids to hepatic vein
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7. Using inulin you determine that the glomerular filtration rate (GFR) is 125 ml/min. You then test drug “X” and find that it has a renal clearance of 125 ml/min. This probably means that A. the drug X is being reabsorbed as well as filtered. B. the drug X is being secreted as well as filtered. C. the drug X is being filtered, secreted and reabsorbed. D.
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test1_answers - Principles of Drug Action (BIO 365) Test #1...

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