TLC - components by passing the fluid over a non-mobile...

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Dhara Bhakta CHEM 237-511 Red October 26, 2008 Thin Layer Chromatography Results S1- caffeine S6- acetaminophen S2- ibuprofen A- Excedrin (my compound) S3- aspirin B- anacin S4-ibuprofen + caffeine C- alleve S5- naproxen sodium Rf for Hexane: all of them were 0 Rf for Ethyl Acetate: S1-.2 S6- .5 S2- .87 A- .786 S3- .83 B- .828 S4-.89 C- .823 S5- .83 Rf for 75% ethyl acetate, 25% hexane S1- .888 S6- .246 S2- .944 A- .694 S3- .690 B- .676 S4-.069 C- .708 S5- .764 Discussion: The purpose of this lab was to use TLC to determine the probable identity of the major active ingredients in commercial analgesic preparations. After performing this experiment, I learned that chromatography is one of the most frequently used organic techniques. It is the process of separating a mixture into its
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Unformatted text preview: components by passing the fluid over a non-mobile absorbent and isolating the components by different absorptions and elutions. The three analgesics that we used were Excedrin, Anacin and Alleve. My analgesic was Excedrin. The solvent I used was hexane. With this my Rf values were all 0 because hexane is nonpolar, thus the spots didn’t move. My partners’ spots moved and the closest ones to the Rf value of my spot were Aspirin, Acetaminophen and Caffeine. The third TLC plate was tested with Aspirin, Acetaminophen and Caffeine in a solvent of ethyl acetate ( best solvent) to help support what my analgesic was most closely related to....
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