08 PLASMID PLANT DEV 2007

08 PLASMID PLANT DEV 2007 - Model genetic organisms dy...

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Model genetic organisms Used to study processes in development, physiology, behavior, reproduction, disease, gene regulation, signal transduction, etc. etc. Traits of models. EASY + CHEAP Small Lots of progeny Fast generation Inexpensive culture Simple Good genetics (diploid or haploid, mutagenesis, crossing) Relevant-normal or does something interesting or useful No “societal” problems Small genome-(sequenced) Transformable
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Examples of model genetic organisms. Escherichia coli (and lambda) Saccharomyces -Baker’s Yeast Drosophila -Fruit fly Mus -Mouse Danio -Zebra fish Xenopus -African Clawed frog Caenorhabditis -Nematode Dictyostelium - Slime mold Arabidopsis Genetics has had a huge resurgence in the past several years. Biochemistry and molecular biology can’t answer all the questions. Functional genomics.
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Examples of model genetic organisms. Escherichia coli (and lambda) Arabidopsis thaliana Very small lots of progeny short generation (30 days) Smallest genome (125 million bases) Easy to grows under many conditions Easy to mutate and do genetics Easy to transform. Has roots, leaves, stems, flowers, fruits, seeds, etc.
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Organism estimated size estimated gene number average gene density chromosome # Homo sapiens (human) 2900 million bases ~30,000 1 gene per 100,000 bases 46 Rattus norvegicus (rat) 2,750 million bases ~30,000 1 gene per 100,000 bases 42 Mus musculus (mouse) 2500 million bases ~30,000 1 gene per 100,000 bases 40 Drosophila melanogaster 180 million bases 13,600 1 gene per 9,000 bases 8 (fruit fly) Arabidopsis thaliana 125 million bases 25,500 1 gene per 4000 bases 5 (plant) Zea mays (corn) 5000 million bases ~25,000 1 gene per 200,000 bases 10 Oryza sativa (rice) 565 ~25,000 1 gene per 23000 bases 12 Caenorhabditis elegans 97 million bases 19,100 1 gene per 5000 bases 6
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This note was uploaded on 11/10/2008 for the course BIO 206L taught by Professor Unknown during the Spring '08 term at University of Texas.

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08 PLASMID PLANT DEV 2007 - Model genetic organisms dy...

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