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PracQs-IMM FINAL 08 - More practice questions for...

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More practice questions for immunology final (see also Bone Marrow Chimera questions) April Apperson, UCSD SOM OESS 1. Which of the following best describes MHC interactions? A. CD3-mediated signaling on a naive TH requires TCR binding to peptide and both subunits of the MHC, and requires CD4 binding to MHC. B. CD4 proteins bind to non-polymorphic beta-2 microglobulin subunit of MHC. C. Each MHC Class I allele can only bind one peptide sequence; e.g., all copies of HLA- A203 on a cell display peptides with identical amino acid sequences. D. TCR and CD8 binding to MHC I proteins activates Zap70 to phosphorylate CD3 ITAMs. E. As a T-cell response progresses, T-cells express CTLA-4, which binds to the nonpolymorphic domains of MHC proteins and decreases T-cell activity. 2. Receptor editing: A. Can occur during B-cell development but cannot occur during T-cell development. B. In developing B-cells occurs due to unproductive heavy chain gene rearrangement. C. In developing B-cells modifies the variable domain exon of the antibody light chain. D. In developing B-cells requires AID (activation-induced cytidine deaminase) function. E. In the thymus determines if a double negative thymocyte will differentiate toward a TCR αβ T-cell or a TCR γδ T-cell. 3. Which of the following most accurately describes HLA types? For questions 4 – 7: 4. Cleaves B into Bb and Ba. 5. C3b bound to this creates a C5 convertase for alternative pathway of complement activation. 6. C3 convertase created as a result antibody-antigen binding in Type II and Type III hypersensitivities.
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