webnotes_genetic_variation_lecture__1009

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Ultimate source of genetic variation MUTATI ON Change in the base (A,T,C,G) sequence of DNA But, how? C T A C A A T C C T A G A A T C C T A A A T C T C T A G A G A T C substitution insertion deletion NEW ALLELES Also inversion and translocation
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Causes of mutation: base sequence scale Errors in DNA replication or repair High-energy radiation (alpha, gamma, x-ray, UV) Chemical mutagens Natural plant alkaloids, such as colchecine (from autumn crocus), vinblastine (from Vinca) that interrupt separation of sister chromatids; nicotine Ethidium bromide – binds to DNA; changes DNA shape Other compounds in environment ~1.6 detectable (loss-of-function) mutations per genome per generation for humans Vinca crocus
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Scale Event Asexual/ Sexual How? Base sequence DNA replication Chromosome Meiosis 1 Gamete Gametic union Organism Mating Sources of genetic variation
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Introductory probability vs.
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# frequency Free Attached (ff) = q 2 Total Allele frequency: variation in the class earlobe p + q = 1.0 p 2 + 2pq + q 2 = 1.0 p 2 pq pq q 2
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Allele frequency: variation in the class earlobe Will allele frequency stay the same in future generations if population is confined to this room?
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This note was uploaded on 03/19/2008 for the course BS 110 taught by Professor S.lawrence during the Fall '07 term at Michigan State University.

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webnotes_genetic_variation_lecture__1009 - Ultimate source...

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