9_-_Development__Aging__and_Death

9_-_Development__Aging__and_Death - Lecture 9 Manipulation...

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Unformatted text preview: Lecture 9: Manipulation of Development, Aging and Death Goals: 1. Define fertilization, conception, cleavage, implantation, embryo, fetal period, birth, maturation, aging & death. 2. Understand ethical dilemmas created by life-sciences. 3. Apply topics to life, science & heath care. Assignment: Websites: http://www.religioustolerance.org/euthanas.htm http://www.religioustolerance.org/abortion.htm http://www.religioustolerance.org/cloning.htm http://www.religioustolerance.org/emb_rese.htm http://www.religioustolerance.org/res_stem2.htm http://prorev.com/genetic.htm http://www.indiana.edu/~engs/cbook/chap2.html http://fertilethoughts.net/faq/asrm/screen.html http://www.leaderu.com/orgs/narth/1995papers/satinover.html http://www.pbs.org/newshour/forum/april98/iq07.html http://hem.passagen.se/nicb/god_ethics.htm What are some of the scientific, ethical, moral and societal challenges associated with Fertilization, Development, Aging and Death? Birth Control, fertilization, abortion, aborted fetal products, stem cells, manipulation of life, manipulation of death… Key Terms • Cloned human embryo • Embryonic stem cell • Blastula, Blastocyst • Pluripotent • Karyotype How does cloning work: • Where does the egg come from • Where does the DNA come from • How many copies of each chromosome Evidence of a Pluripotent Human Embryonic Stem Cell Line Derived from a Cloned Blastocyst Woo Suk Hwang et al. 1 College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea; • Somatic cell nuclear transfer. • Pluripotent embryonic stem cell line • Cloned human blastocyst. Maturation …but imperfect Lizards and salamanders can regenerate limbs and tails …perfectly! HOW?????-Burns-Scars Regeneration } Human – Capable of differentiating into embryoid bodies – Containing cell derivatives from all three embryonic germ layers • Capable of continuous proliferation for >70 passages • Cells maintain normal karyotypes uterus ovary oviduct endometrium IMPLANTATION FERTILIZATION inner cell mass Fig. 39.21a, p. 666 Endometrium Uterine cavity Blastocoel Trophoblast (surface layer of cells of the blastoyst) inner cell mass Start of amniotic cavity Start of embryonic disk Start of yolk sac Blood-filled spaces Start of chorionic cavity DAYS 6-7 DAYS 10-11 DAY 14 DAY 12 yolk sac Chorionic cavity Shorionic villi Shorion Smniotic cavity Connecting stalk Fig. 10.8, p. 158 Nucleus of a diploid (2n) Reproductive cell with two pairs of homologous chromosomes OR Possible alignments of the two homologous chromosomes during metaphase I of meiosis The resulting alignments at metaphase II: allelic combinations possible in gametes: 1/4 AB 1/4 ab 1/4 Ab 1/4 aB A A A A A A A A A A A A B B B B B B B B B B B B a a a a a a a a a a a a b b b b b b b b b b b b Meiosis Egg Zona Pellucida Corona Radiata Tail Mitochondria Acrosome Cortical Granules Fertilization- The Big Event Sperm Egg Nucleic Acid: DNA Zona pellucida Follicle cell Granules in cortex of cytoplasm Nuclei fuse FERTILIZATION OVULATION Oviduct Ovary Uterus Opening of cervix Vagina Sperm enter vagina Fetal Period...
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This note was uploaded on 03/19/2008 for the course ISB 201 taught by Professor Besaw during the Spring '08 term at Michigan State University.

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9_-_Development__Aging__and_Death - Lecture 9 Manipulation...

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