Chapter 15 - Chapter 15 How Genes Work 15.1 What Do Genes...

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Chapter 15: How Genes Work 15.1: What Do Genes Do? o Archibald Garrod provided the fist clue in the mystery of how genes work o The Molecular Basis of Hereditary Disease Alkaptonuria, disease which is characterized by arthritis and other symptoms Metabolic Pathway Each enzyme is catalyzed by a different enzyme If the enzyme is not available, the reaction that is catalyzes does not occur, and the substrate for that particular reaction accumulates Genes and Enzymes George Beadle and Edward Tatum o One-gene, one-enzyme hypothesis 15.2: The Genetic Code: o RNA as the Intermediary between Genes and Proteins mRNA Messenger RNA Carry information from DNA to the site of protein synthesis RNA polymerase Catalyzes the synthesis of RNA Polymerizes ribonucleotides into strands of RNA Synthesizes RNA molecules according to the information provided by the sequence of vases in a particular stretch of DNA
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