LectureSept24

LectureSept24 - BME 423 Lecture Notes - Sept. 24, 2008...

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Hypothesis Testing Special Case of Two Groups BME 423 Lecture Notes - Sept. 24, 2008 II. Multiple Comparisons A. Bonferroni B. Holm t Test III. Multiple Comparisons Against a Single Control A. Bonferroni B. Holm t Test IV. The Meaning of P (read presentation in book) Chapt 4: p 73-104 p 111-113 p 117 - 122
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ANOVA 2 2 bet wit s F s = 1 (1 ) n d m mn ν = = (, ) nd FF α νν > P < Reject H0 with: 12 0: m H μ μμ = == "
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() tt α ν > 12 2 nn ν= +− t Test P < Reject H0 with: 0: H μ = 22 xx t s s = +
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II. Multiple Comparisons –Bonferroni t Test Bonferroni inequality: T k α α= Overall level of Significance (e.g., 0.05) T k < # of pair-wise comparisons significance to use for each pair-wise comparison For each t test comparison use: 22 Also (1 ) wit ss mn ν =
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II. Multiple Comparisons –Holm t Test Idea: Use successively larger significance levels # of pair-wise comparisons significance to use for the j th pair-wise comparison Overall level of significance (e.g., 0.05) (1 ) T j kj α α= + 1, j = 1 2 3 3 0.0167 largest diff in 0.025 0.05 smallest diff in k x x = = = = # For example:
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Problem 3.3 From Glantz
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This note was uploaded on 12/02/2008 for the course BME 423 taught by Professor D'argenio during the Fall '06 term at USC.

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LectureSept24 - BME 423 Lecture Notes - Sept. 24, 2008...

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