LectureDec1

LectureDec1 - BME 423 Lecture Notes Dec 1 2008 I Clinical...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
1 BME 423 Lecture Notes - Dec. 1, 2008 I. Clinical Studies A. Experimental Studies B. Observational Studies II. What do the Data Show? A. Randomize and Control B. Problems with the Population III. Ethical Issues and Clinical Trials A. Declaration of Helsinki Glantz • pp 21-29 • Chapt. 12 • Handouts
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Lind Experiment on Scurvy I. Clinical Studies
Background image of page 2
3 RCT Fundamental Design Eligible Consent R A N D O M I Z E No No Dropped Dropped Yes Yes B A Comment : Compare A with B Experimental Studies: •Advantages - Randomization tends to produce comparable groups - Randomization produces valid statistical tests •Disadvantage - Generalizable Results? Subjects may not represent general patient population – volunteer effect - Acceptability of Randomization Process Some physicians will refuse Some patients will refuse Ethical issues of randomization
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Randomized Cross-Over Design Scheme Period Group I II AB 1 TRT A TRT B BA 2 TRT B TRT A Advantage Each patient their own control Smaller sample size
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/03/2008 for the course BME 423 taught by Professor D'argenio during the Fall '06 term at USC.

Page1 / 7

LectureDec1 - BME 423 Lecture Notes Dec 1 2008 I Clinical...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online