Eugene Quackenbush

Eugene Quackenbush - o • The activated T cell releases...

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\ Eugene Quackenbush Immunology 419 October 26 th , 2008 Immunology Midterm Exam 1) Summary of activation of naive mature invasin-specific B cells to become mature IgA- secreting plasma cells A mature naïve B cell is one that has not been exposed to antigen and has surface immunoglubulin Immunoglobulin on surface of naïve B cell recognizes antigen B cell ingests the antigen and presents it on its surface, in addition to MHC class II, to be recognized by T cells Once the T cell recognizes the antigen on the B cell, a conjugate via bonding of the T cell receptors and the antigen and MHC II complex, both cells receive a “contact” signal during this interaction. At this point the pathway for T cell activation begins
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Unformatted text preview: o • The activated T cell releases cytokines (specifically Il-2 and Il-4) that, in addition to the “contact” signal, induce proliferation in the B cell • In response to coming into contact with antigen, the B cells will secrete antibody, the first antibody that is secreted is IgM. This is also known as the primary response. 2a) Discuss the structure and function of the intestinal tissue, especially the M cell and how it contributes to host defenses? The gastrointestinal tract is among the most vulnerable membrane surfaces in the body as is one of the major sites at which pathogens enter body tissues. +...
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