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Unformatted text preview: GENETICS (BIO 325) SPRING 2008 Discussion sheet 8 key _____________________________________________________________________________ _ 1. Choice (c) is the correct answer. A mutation in the isoleucyl-tRNA synthetase that decreases its ability to distinguish between amino acids would allow an assortment of amino acids to be attached to the tRNA Ile . These assorted aminoacyl-tRNAs would then base-pair with the isoleucine codon and cause a variety of substitutions at positions normally occupied by isoleucine. Choice (a) is incorrect because a mutation in the gene encoding the protein would cause only a single variant protein to be made. Choice (e) is incorrect because a mutation in the ribosome that allows binding of any amino-acyl-tRNA to the A site would cause substitutions all over the protein, not only at isoleucine residues. Choices (b) and (d) are also incorrect. A mutation in the anticodon loop of tRNA Ile (choice (b)) or a mutation in the isoleucine-tRNA synthetase that decreases its ability to distinguish between different tRNA molecules (choice (d)) would cause substitution...
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