Discussion Sheet 10 - GENETICS (BIO 325) Spring 2008...

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GENETICS (BIO 325) Spring 2008 Discussion sheet 10 _____________________________________________________________________________ _ 1. Show the steps (i.e., several replications) by which 5-bromouracil causes the GC base pair shown below to change to an AT base pair. Show the point at which the rare (tautomeric) form of 5-bromouracil gets incorporated in the DNA. Show both products of all divisions in which 5-bromouracil is involved. Do not show chemical structures. 2. Sequential mutations affecting one codon caused the changes arg thr met leu gln What base pair changes produced these amino acid changes? 3. The rare enol form of thymine pairs with guanine. If a thymine enolization occurs during replication, what would be the mutational event? A) CG to AT B) GC to TA C) AT to TA D) TA to CG E) CG to GC 4. After mutagen treatment, a molecule of 2-aminopurine (an adenine analogue) incorporates into DNA. During replication the 2-AP protonates. The mutational event caused by this will be A) AT to CG B) GC to AT C) AT to TA D) AT to GC E) GC to CG 1
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5. Fragile X syndrome is caused by
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This note was uploaded on 12/08/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

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Discussion Sheet 10 - GENETICS (BIO 325) Spring 2008...

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