somatic recombination notes

somatic recombination notes - presence of the B-cell, this...

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Somatic Recombination In a world filled with viruses and bacteria all out to kill us, the human immune system has to have a way to defend our bodies It has antibodies, created in the B-lymphocyte white blood cells o Antibodies are Y-shaped glycoproteins that are created as a defense response when the B-cells detect a foreign object o The antibodies are made up of 4 polypeptide chains, 2 light chains (red) and 2 heavy chains (blue) and variable antigen-binding sites on the top of the “Y” where the antibody binds to the virus or bacteria When the antibody has bonded to the virus or bacteria in the
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Unformatted text preview: presence of the B-cell, this creates a response in the B-cell to make more of that antibody So many kinds of antibodies o Each B-cell can produce its own kind of antibody Only can have same # antibodies as # B-cells o How? Susumu Tonegawa o In the early 1970s, Tonegawa studied the creation of antibodies in B-cells o What he discovered earned him the Nobel prize for Physiology and Medicine in 1987 How Somatic Recombination works o Splicing of gene o Transcription of spliced gene o Translation of mRNA o Finished antibody...
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somatic recombination notes - presence of the B-cell, this...

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