lecture_09_26

lecture_09_26 - Resting Membrane Potential Lectures What...

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What you will learn in these lectures 1. You will learn that all cells, including neurons, have a resting membrane potential. 2. You will learn that two conditions are necessary to produce a voltage across a cell membrane (CM). 1) There must be a concentration difference for at least one species of ion across the CM. 2) The membrane must also be permeable to at least one species of ion. 3.You will learn that two forces will act on ions. 1) A chemical diffusion force and 2) an electrical force. 4.You will learn that a charge difference (voltage) is created across the CM as a result of the chemical and electrical forces. 5.You will learn how to quantify the magnitude of the chemical and electrical forces acting on ions. 6.You will learn that the Nernst equation can be used to predict the potential across the CM for a particular species of ion. 7.You will learn that the Nernst equation is insufficient to predict the voltage across a membrane permeable to multiple ions. 8.You will learn that the GHK equation can be used to predict the potential across a CM permeable to multiple ions. 9.You will learn that the Nernst equation can be used to calculate the equilibrium potential for any ion across a CM. 10.You will learn that if the permeability to an ion is increased and all other variables are held constant then the membrane potential will always shift towards the equilibrium potential of that ion. 11.You will use the equations & rules from lecture to predict the magnitude & direction of the forces acting on ions when the cell is at rest. 12.You will learn how ATP-dependent pumps counteract the forces acting on ions at rest to maintain a constant membrane potential. Resting Membrane Potential Lectures
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I.B.3. Two initial conditions are necessary to produce a voltage across the CM I.B.2. Every cell has a voltage across its cell membrane The voltage on the of the cell is measured relative to the .
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This note was uploaded on 12/10/2008 for the course NPB 100 taught by Professor Chapman during the Fall '08 term at UC Davis.

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lecture_09_26 - Resting Membrane Potential Lectures What...

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