Nov4 - Required Reading Chapter 10 Chapter 11 11.1 11.2(341-343 11.3 11.4 11.7(361-366 Chapter 12 11.6 short nucleic acids(<150b are routinely

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• Required Reading • Chapter 10 • Chapter 11: 11.1, 11.2(341-343), 11.3, 11.4, 11.7(361-366) • Chapter 12 • 11.6: short nucleic acids (<150b) are routinely synthesized
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• The basic chemistry and structures of nucleotides (bases, sugars, phosphate) • From nucleotides to nucleic acids • The information stored in nucleic acids • The biological functions of nucleotides and nucleic acids?
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The basic structures • Pyrimidines – Cytosine (DNA, RNA) – Uracil (RNA) – Thymine (DNA) • Purines – Adenine (DNA, RNA) – Guanine (DNA, RNA)
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Properties of Pyrimidines and Purines • Keto-enol tautomerism • Acid/base dissociations • Strong absorbance of UV light
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Fig. 10-07, p.311
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Fig. 10-06, p.311
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Functions of Nucleotides • Nucleoside 5'-triphosphates are carriers of energy • Bases serve as recognition units • Cyclic nucleotides are signal molecules and regulators of cellular metabolism and reproduction • ATP is central to energy metabolism • GTP drives protein synthesis • CTP drives lipid synthesis • UTP drives carbohydrate metabolism
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• The Different Classes of Nucleic Acids • Susceptibility of Nucleic Acids to Hydrolysis
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Different Classes of Nucleic Acids • DNA - one type, one purpose • RNA - >3 (or >4) types, >3 (or >4) purposes – ribosomal RNA - the basis of structure and function of ribosomes – messenger RNA - carries the message – transfer RNA - carries the amino acids
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This note was uploaded on 12/12/2008 for the course WHO CARES 23948 taught by Professor Asshole during the Spring '08 term at University of Houston.

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Nov4 - Required Reading Chapter 10 Chapter 11 11.1 11.2(341-343 11.3 11.4 11.7(361-366 Chapter 12 11.6 short nucleic acids(<150b are routinely

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