3. Gene+Regulation

3 Gene Regulation - BIO313 Lectures 3-12 Cell Biology A glimpse at a few selected themes Regulation of gene expression Nucleocytoplasmic transport

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
BIO313 Lectures 3-12 Cell Biology: A glimpse at a few selected themes … Regulation of gene expression Nucleocytoplasmic transport Protein folding, protein domains, protein degradation Cytoskeleton Cell-cell adhesion/cell-substrate adhesion Cell motility …and a taste of how to approach them experimentally
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The Wnt- β -catenin signaling pathway: A thread that links these various themes
Background image of page 2
The Wnt- β -catenin signaling pathway PATHWAY OFF PATHWAY ON Wnt β -catenin β -cateni n α -catenin cadherins actin DEGRADATION D s h β -catenin TCF β -catenin GENE REGULATION NUCLEAR TRANSPORT nucleus cytoplasm plasma membrane CELL ADHESION
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
TCF β -catenin Gene regulation
Background image of page 4
Nucleo-cytoplasmic transport nucleus cytoplasm
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
β -catenin Protein domains Protein folding
Background image of page 6
Protein degradation β -catenin
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
actin plasma membrane Cytoskeleton
Background image of page 8
β -catenin α cadherins actin plasma membrane Cell adhesion
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background reading in Molecular Biology of the Cell, Alberts et al 4 th Edition Regulation of gene expression DNA, gene regulatory proteins, protein-DNA binding: pp 192-197 + 379-394 Bacterial genetic switches: pp 395-398 Chromatine structure: pp 207-216 Regulation of transcription: pp 398-415
Background image of page 10
Regulation of gene expression Part 1: A) General introduction B) Gene regulatory proteins C) Methods to study protein-DNA interactions
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Control of gene expression 1 DNA for all RNAs and proteins All of the RNA and protein molecules required to construct the cells of an organism are encoded in its DNA. 2 Many different cell types The different cell types of a multicellular organism differ dramatically in structure and function as a result of differentiation. 3 Different RNAs + proteins The genome is preserved during cell differentiation, but different cell types accumulate different populations of RNA and protein as a consequence of changes in gene expression.
Background image of page 12
Protein composition and cell differentiation 1. Proteins involved in basic cellular processes are common to all cells. structural proteins of chromosomes
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 14
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/16/2008 for the course BIOL 313 taught by Professor O during the Spring '08 term at McGill.

Page1 / 41

3 Gene Regulation - BIO313 Lectures 3-12 Cell Biology A glimpse at a few selected themes Regulation of gene expression Nucleocytoplasmic transport

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online