PHGY 209 Immunology Lecture I Notes

PHGY 209 Immunology - P HGY 209 I m munology Lecture I Notes Th ree lines of host defense 1 The coverings of the body skin and mucous membranes do

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PHGY 209 Immunology Lecture I Notes October 18, 2008 Three lines of host defense 1. The coverings of the body – skin and mucous membranes - do not require immunity if this covering is not breached. 2. Innate immune response – hard wired, same in virtually all mammals most critical part of the immune system has no memory 3. The adaptive immune response Phagocytic cells Polymorph –neutrophil. Has multiple nuclei-phagocytic. Dendritic cell Macrophage- Equally phagocytic- carry bacteria on its surfaces. Inflammation Manifestation of Innate immune response. Redness, heat, swelling, pain. Danger signal sent by bacteria. Foreigness without danger may not elicit a good immune response. Macrophage comes along and takes a bite of bacteria and then calls in neutrophil. Neutrophil phagocyte the bacteria and dies. Hence that is why there is no memory associated with innate immune response. Macrophage goes back to the regional lymph node and calls in dendritic cell, this is a
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This note was uploaded on 12/25/2008 for the course PHGY PHGY 209 taught by Professor Annwechsler during the Spring '08 term at McGill.

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PHGY 209 Immunology - P HGY 209 I m munology Lecture I Notes Th ree lines of host defense 1 The coverings of the body skin and mucous membranes do

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