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Unformatted text preview: PHGY 209 Immunology Lecture I I I October 18, 2009 Neutrophil Microbe is digested oxidatively in the phagolysosome. Phagolysosome explodes into the cytoplasm, this also kills the cell to form pus. Some may spew into the interstitial space to cause pain. Dendritic cell Professional antigen presenting cell- why? Because in the first part of its life, it is phagocytic. Shortly after, it becomes synthetic cell. It produces MHC I I proteins. One microbe may give rise to lots of MHC I I protein-peptide complexes. Nothing specific has happened so far. We are still in the innate immune response. The football game Converings – fluids mucin, skin, mucus membrane, cilla (unfriendly) Innate immunity- macrophage, dendritic cell, neutrophils ( phagocytic, no memory) Adapative immunity- B cell, Tc, Th, I Ls, Ig ( Specificity and memory) T helper cell T helper cell falls below 50%, threat of dying. Lymphoepithelial organs Epithelial organs with lymphocytes in them – thymus and bursa of fabricius (in the chicken) Chicken experiment If you remove bursa of fabricius from the chickens, they cannot make antibodies. The cells made from bursa of fabricius are B lymphocytes....
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This note was uploaded on 12/25/2008 for the course PHGY PHGY 209 taught by Professor Annwechsler during the Spring '08 term at McGill.
- Spring '08