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Physio Lecture.docx - LECTURE Second exam ANS sensory...

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LECTURE 09/20/2017 Second exam : ANS, sensory nervous system, and motor system (maybe/maybe not) Autonomic Nervous System (ANS): The ANS is part of the nervous system that controls and innervates the internal organs (thoracic, abdominal, and pelvic cavities), sweat glands, the smooth muscles of blood vessels, etc. There are two parts: Parasympathetic (PNS) and Sympathetic (SNS) Effect of neurotransmitter depends on the type of receptor and location of receptor. The origin of sympathetic nervous system is T1-L2/L3 (Thoracolumbar) The parasympathetic nervous system originates from CN 3,7,9,10 AND S2-S4. PNS also known as the craniosacral nervous system. Types of receptors: Parasympathetic nervous system: Ach – cholinergic receptor (two types: nicotinic and muscarinic receptor) Sympathetic nervous system: Norepinephrine – Adrenergic receptors (Alpha, Beta, and Dopamine) PICTURE – SYMPATHETIC SYSTEM 1. Norepinephrine is released from the postganglionic system 2. Requires Alpha 1 and Beta 1 receptors a. Alpha 1 – adrenergic receptor located in smooth muscles of blood vessels, smooth muscles of the GI tract, sweat glands, and the sphincter of the urinary bladder. Preganglionic fiber travels through the sympathetic exchange and meets postganglionic fiber travels to internal organs Pre ganglionic releases Ach and post ganglionic released Norepinephrine Preganglionic fiber of SNS releases ACH which has cholinergic receptor on post ganglionic fiber. After binding with post it activates post ganglionic Synapsis occurs where inside the ganglion. Post ganglionic fiber releases Norepinephrine requires specific receptor in internal organs (Alpha 1 and 2, Beta 1 and 2) PICTURE – EFFECT OF NOREPINEPHRINE ON ALPHA 1 RECEPTOR Over secretion of norepinephrine, what kind of side effect may it have on blood pressure?
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