BS110 DNA Structure and Replication

BS110 DNA Structure and Replication - Organisms and...

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Organisms and Populations The Molecular Basis of Inheritance BS 110 8 February 2008 0
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DNA DNA is the genetic material of all living organisms Nucleic acid Inherited from parents Precisely replicated some mistakes recombination Able to direct its own replication (with RNA) Hereditary information encoded in chemical language Reproduced in all cells of body Directs development and maintenance of virtually all traits 0
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Discovery of the genetic material Known to be on chromosomes since 1920s Proteins or DNA? Until the 1940s, most thought proteins were the genetic material Proteins complex, numerous DNA is simple, repetitive, with just four bases Evidence from cell division: DNA doubles before duplication of genetic material for cell division Distributed equally to two daughter cells Body cells have twice the DNA of sex cells True identity of genetic material as DNA only determined in 1952 by experiments with microorganisms 0
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Structure of DNA Knowledge of role raised 2 major questions: 1) how does DNA hold the genetic information? 2) how is DNA copied? Answer to first in 1953, by Watson & Crick Correctly suggested main answer to second
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Composition of DNA DNA a polymer of three components Nitrogenous base Adenine (A) Thymine (T) Guanine (G) Cytosine (C) Pentose (5-carbon) sugar,
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