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DAAD_Project2_MoecularCellBiology.pdf

DAAD_Project2_MoecularCellBiology.pdf - Project 2(Molecular...

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Project 2 (Molecular & Cell Biology, Saarland University) Intracellular trafficking and mis-trafficking of disease-related plasma membrane proteins in yeast and mammalian cells Correct subcellular protein localization is not only essential for normal protein function, it likewise determines proper access to individual interacting partners and specific post- translational modifications. Consequently, aberrantly localized proteins have been linked to a wide range of human diseases including Alzheimer, cancer and even kidney stones (1). In the current PhD project, expression and subcellular targeting of two types of plasma membrane proteins will be investigated in both, yeast and mammalian cells: (i) Wild-type and clinically relevant mutant variants of human anion exchanger AE1, and (ii) KDEL receptors (KDELR) and their compartmental distribution between the Golgi, the endoplasmic reticulum (ER) and the plasma membrane. Altered trafficking of the anion exchange transporter 1 (AE1) can cause a genetically inherited disease - distal renal tubular acidosis (dRTA) - which can be linked to various mutations within the chromosomal SLC4A1 gene (2). Normally, AE1 is expressed at the
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