Lecture 01 2B03 2017.pptx - Biochemistry 2B03 Nucleic Acid...

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Biochemistry 2B03 Nucleic Acid Structure and Function Instructors: Karun Singh and Kristin Hope Stem Cell and Cancer Research Institute
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Nucleic Acids: DNA and RNA RNA: r ibo n ucleic a cid DNA: d eoxyribo n ucleic a cid DNA and RNA are extremely large biological polymers of repetitive units each made of a sugar, an aromatic base and phosphodiester linkage
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Central Dogma of Biological Function Crick, 1958 Protein RNA DNA Replication: DNA directed DNA synthesis Blueprint of genomic information Transcription: DNA directed- RNA synthesis Message carrying the genomic information Translation: RNA directed protein synthesis Final Product
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Nucleic Acids: Known Functions / Utility Genetic material (DNA mainly; RNA also) Enzymes (ribozymes and deoxyribozymes) Regulators of Protein (microRNAs, siRNAs and shRNAs, etc) Molecular machines (ribosomes and splicosomes) Drugs or Therapies (Vitravene – antisense; RNA interference)
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Applications of Nucleic Acids -DNA sequencing (eg. disease mutations) -DNA nanomachines -RNA interference -Genome editing (Crispr/Cas9) -Gene therapy -Disease modeling (eg. mouse models – knockouts or genetic knock-ins) -Biosensors Crispr/Cas9
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Nobel Prize Winners on Nucleic Acids Year/Subject Winners Contributions 1959/Medicin e Severo Ochoa and Arthur Kornberg Biosynthesis of DNA and RNA 1962/Medicin e Frances Crick, James Watson and Maurice Wilkins DNA structure 1965/Medicin e François Jacob, André Lwoff and Jacques Monod Genetic control of enzyme and virus synthesis 1968/Medicin e
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