Lecture 02 2B03 2017.pptx - Lecture 2 Nucleotides and...

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Lecture 2 Nucleotides and Nucleic Acids Part I
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4 Essential Questions to Remember What are the structures of the nucleotides? How are nucleotides joined together to form nucleic acids? How is information stored in nucleic acids? What are the biological functions of nucleic acids?
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Information Transfer in Cells Fundamental process of information transfer in cells. Information encoded in a DNA molecule is transcribed via synthesis of an RNA molecule The sequence of the RNA molecule is "read" and translated into the sequence of amino acids in a protein
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Chemical Structures of Nitrogenous Bases Pyrimidines (Py) Cyt osine (DNA, RNA) Ur acil (RNA) Thym ine (DNA) Purines (Pu) Aden ine (DNA, RNA) Guan ine (DNA, RNA) Underlined is the root of each name
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Purines and Pyrimidines (a) Pyrimidine ring and (b) purine ring systems; atoms are numbered as indicated please memorize . Carbon (C)
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Three Pyrimidine Bases Chemical structures of cytosine, uracil, and thymine please memorize.
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Two Purine Bases The common purine bases – adenine and guanine please memorize .
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Chemical Structures of Nucleosides Nucleosides are compounds formed when a base is linked to a sugar via a Glycosidic Bond The sugars are pentoses (5 Carbon based) D-ribose (in RNA) 2-deoxy-D-ribose (in DNA) The difference - 2'-OH vs 2'-H This difference affects secondary structure and stability
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Ribose (in RNA) The linear and cyclic (furanose) forms of ribose.
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