Unit 2-Lecture 2.pptx - Unit 2-Blood Lecture 2-Blood...

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Unit 2-Blood Lecture 2-Blood Clotting
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A series of reactions for stoppage of bleeding During hemostasis, three phases occur in rapid sequence Vascular spasms – immediate vasoconstriction in response to injury Platelet plug formation Coagulation (blood clotting) Hemostasis
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Platelets do not stick to each other or to blood vessels Upon damage to blood vessel endothelium platelets: With the help of von Willebrand factor (VWF) adhere to collagen Are stimulated by thromboxane A 2 Stick to exposed collagen fibers and form a platelet plug Release serotonin and ADP, which attract still more platelets The platelet plug is limited to the immediate area of injury by prostacyclin Platelet Plug Formation
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A set of reactions in which blood is transformed from a liquid to a gel Coagulation follows intrinsic and extrinsic pathways The final three steps of this series of reactions are: Prothrombin activator is formed Prothrombin is converted into thrombin Thrombin catalyzes the joining of fibrinogen into a fibrin mesh Coagulation
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Coagulation Figure 17.13a
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