Biol 216 5 The Neuron 151-175.pdf

Biol 216 5 The Neuron 151-175.pdf -...

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5/18/17 1 Neurotransmission (chemical synapse) Key Players Neurotransmitters Synaptic vesicles: store neurotransmitters in cytoplasm of axon terminal Neurotransmitters:releasedby exocytosis when action potential arrives at terminal Voltage gatedCa 2+ channels open, allowing Ca 2+ toflow into the axon terminal (presynaptic cell) Vesicles fuse with membrane and release neurotransmitters into synaptic cleft Neurotransmission (chemical synapse) When stimulus subsides, no action potentials are generated, voltage gated Ca 2+ channels close Ca 2+ is pumped outside of the axon terminal, vesicles no longer fuse with membrane Any remaining neurotransmitters in the cleft diffuse away or are broken down
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5/18/17 2 Neurotransmission at the Chemical Synapse Removal of Neurotransmitter fromSynaptic Cleft 11-154
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5/18/17 3 Neurotransmission (chemical synapse) Ligand gated ion channels open on the post synaptic cell membrane when the neurotransmitter binds to them Flow on ionscan stimulate or inhibit the generation of an action potential in the post synaptic cell Neurotransmission (chemical synapse)
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