Hepatitis PPT Student SP17.pptx - HEPATITIS Concepts...

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HEPATITIS Concepts
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Pathophysiology Viral infection leading to inflammation of the liver Chronic when > 6 months Classifications: A, B, C, D, E
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Hepatitis A Virus (HAV) RNA of enterovirus family Fecal-oral transmission Mild/flu like course Usually self-limiting, not chronic Vaccine available and can prevent it Antiviral post exposure available
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Hepatitis B Virus (HBV) Double-shelled particle DNA composed antigen Blood-borne, perinatal Acute and Chronic GI symptoms, pain, jaundice, fatigue, dark urine, clay colored stool Most recover and receive immunity Risk of liver disease and liver cancer; may need a transplant Vaccine available for prevention Antivirals and IgM post exposure available
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Hepatitis C Virus (HCV) Enveloped, single-stranded RNA virus Blood-borne, perinatal Chronic infection in 70-80% of cases; 20% will develop cirrhosis Most unaware they have it Number one reason for liver transplant No vaccine for prevention available Combination of medications for treatment available
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Hepatitis D Virus (HDV) Delta, defective RNA virus Needs helper function of HBV to cause viral replication Blood-borne Most often leads to chronic hepatitis Risk of Fulminant Hepatitis
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Hepatitis E Virus (HEV) Water-borne in other countries Fecal-oral
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