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d3bbdfc7cc884d7d91f82ee38a5527e8_32a3c04ac416f8d3c4e26b2cdb271998.docx

D3bbdfc7cc884d7d91f82ee38a5527e8_32a3c04ac416f8d3c4e26b2cdb271998.docx

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We wish to assess a new intervention aimed at reducing the serum uric acid levels in patients with gout. To do this a randomized control trial is to be the conducted, where patients are randomized to either the new intervention or the control arm, which receives standard care. At the initial planning stage, the chief investigator stated that it will be feasible to recruit 100 patients in total for the study (50 in each arm). From a pilot study the pooled standard deviation was estimated to be 2 mg/100 mL. The planned analysis at the end of the study is to compare the mean serum uric acid levels between the two groups using a two-sample t-test and 5% significance level. Let the true mean serum uric acid level in the control group and intervention be notated ? ? and
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